PhytophthoraV1, Main, Exploration, bibRecord, 000A63

An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.

Identifieur interne : 000A63 ( Main/Exploration ); précédent : 000A62; suivant : 000A64

An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.

Source :

Nature communications [ 2041-1723 ] ; 2017.

RBID : pubmed:29233978

Descripteurs français

KwdFr :
- ARN des plantes (génétique), Analyse de séquence d'ARN (MeSH), Facteurs de virulence (métabolisme), Immunité des plantes (génétique), Interactions hôte-pathogène (génétique), Interactions hôte-pathogène (immunologie), Maladies des plantes (génétique), Maladies des plantes (immunologie), Phytophthora (pathogénicité), Phytophthora (physiologie), Protéines de soja (génétique), Protéines de soja (métabolisme), Précurseurs des ARN (génétique), Régulation de l'expression des gènes végétaux (immunologie), Soja (génétique), Soja (immunologie), Soja (parasitologie), Splicéosomes (génétique), Splicéosomes (métabolisme), Épissage alternatif (MeSH).
MESH :
- génétique : ARN des plantes, Immunité des plantes, Interactions hôte-pathogène, Maladies des plantes, Protéines de soja, Précurseurs des ARN, Soja, Splicéosomes.
- immunologie : Interactions hôte-pathogène, Maladies des plantes, Régulation de l'expression des gènes végétaux, Soja.
- métabolisme : Facteurs de virulence, Protéines de soja, Splicéosomes.
- parasitologie : Soja.
- pathogénicité : Phytophthora.
- physiologie : Phytophthora.
- Analyse de séquence d'ARN, Épissage alternatif.

English descriptors

KwdEn :
- Alternative Splicing (MeSH), Gene Expression Regulation, Plant (immunology), Host-Pathogen Interactions (genetics), Host-Pathogen Interactions (immunology), Phytophthora (pathogenicity), Phytophthora (physiology), Plant Diseases (genetics), Plant Diseases (immunology), Plant Immunity (genetics), RNA Precursors (genetics), RNA, Plant (genetics), Sequence Analysis, RNA (MeSH), Soybean Proteins (genetics), Soybean Proteins (metabolism), Soybeans (genetics), Soybeans (immunology), Soybeans (parasitology), Spliceosomes (genetics), Spliceosomes (metabolism), Virulence Factors (metabolism).
MESH :
- chemical , genetics : RNA Precursors, RNA, Plant, Soybean Proteins.
- genetics : Host-Pathogen Interactions, Plant Diseases, Plant Immunity, Soybeans, Spliceosomes.
- immunology : Gene Expression Regulation, Plant, Host-Pathogen Interactions, Plant Diseases, Soybeans.
- chemical , metabolism : Soybean Proteins, Spliceosomes, Virulence Factors.
- parasitology : Soybeans.
- pathogenicity : Phytophthora.
- physiology : Phytophthora.
- Alternative Splicing, Sequence Analysis, RNA.

Abstract

The process of RNA splicing influences many physiological processes, including plant immunity. However, how plant parasites manipulate host RNA splicing process remains unknown. Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant pathogen Phytophthora sojae, physically binds to and stabilizes soybean serine/lysine/arginine-rich proteins GmSKRPs. The SKRPs are novel proteins that associate with a complex that contains plant spliceosome components, and are negative regulators of plant immunity. Analysis by RNA-seq data indicates that alternative splicing of pre-mRNAs from 401 soybean genes, including defense-related genes, is altered in GmSKRP1 and PsAvr3c overexpressing lines compared to control plants. Representative splicing events mediated by GmSKRP1 and PsAvr3c are tested by infection assays or by transient expression in soybean plants. Our results show that plant pathogen effectors can reprogram host pre-mRNA splicing to promote disease, and we propose that pathogens evolved such strategies to defeat host immune systems.

DOI: 10.1038/s41467-017-02233-5
PubMed: 29233978
PubMed Central: PMC5727057

Affiliations:

Canada, République populaire de Chine

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.</title>
<author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
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<author><name sortKey="Gu, Lianfeng" sort="Gu, Lianfeng" uniqKey="Gu L" first="Lianfeng" last="Gu">Lianfeng Gu</name>
<affiliation wicri:level="1"><nlm:affiliation>Basic Forestry and Proteomics Research Center, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Basic Forestry and Proteomics Research Center, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou, 350002</wicri:regionArea>
<wicri:noRegion>350002</wicri:noRegion>
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<author><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name>
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<author><name sortKey="Yan, Tingxiu" sort="Yan, Tingxiu" uniqKey="Yan T" first="Tingxiu" last="Yan">Tingxiu Yan</name>
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<author><name sortKey="Kong, Liang" sort="Kong, Liang" uniqKey="Kong L" first="Liang" last="Kong">Liang Kong</name>
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<author><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name>
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<author><name sortKey="Qiu, Min" sort="Qiu, Min" uniqKey="Qiu M" first="Min" last="Qiu">Min Qiu</name>
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<author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name>
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<author><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name>
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<wicri:noRegion>210095</wicri:noRegion>
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<author><name sortKey="Xing, Weiman" sort="Xing, Weiman" uniqKey="Xing W" first="Weiman" last="Xing">Weiman Xing</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602</wicri:regionArea>
<wicri:noRegion>201602</wicri:noRegion>
</affiliation>
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<author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
<wicri:noRegion>210095</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation>
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<author><name sortKey="Wu, Zhe" sort="Wu, Zhe" uniqKey="Wu Z" first="Zhe" last="Wu">Zhe Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, 518055, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, 518055</wicri:regionArea>
<wicri:noRegion>518055</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Zhengguang" sort="Zhang, Zhengguang" uniqKey="Zhang Z" first="Zhengguang" last="Zhang">Zhengguang Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
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<author><name sortKey="Zheng, Xiaobo" sort="Zheng, Xiaobo" uniqKey="Zheng X" first="Xiaobo" last="Zheng">Xiaobo Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
<wicri:noRegion>210095</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation>
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<wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea>
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<author><name sortKey="Gijzen, Mark" sort="Gijzen, Mark" uniqKey="Gijzen M" first="Mark" last="Gijzen">Mark Gijzen</name>
<affiliation wicri:level="1"><nlm:affiliation>Agriculture and Agri-Food Canada, London, ON, N5V 4T3, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Agriculture and Agri-Food Canada, London, ON, N5V 4T3</wicri:regionArea>
<wicri:noRegion>N5V 4T3</wicri:noRegion>
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<author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
<wicri:noRegion>210095</wicri:noRegion>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea>
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<author><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China. smdong@njau.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
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<series><title level="j">Nature communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2017" type="published">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alternative Splicing (MeSH)</term>
<term>Gene Expression Regulation, Plant (immunology)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Host-Pathogen Interactions (immunology)</term>
<term>Phytophthora (pathogenicity)</term>
<term>Phytophthora (physiology)</term>
<term>Plant Diseases (genetics)</term>
<term>Plant Diseases (immunology)</term>
<term>Plant Immunity (genetics)</term>
<term>RNA Precursors (genetics)</term>
<term>RNA, Plant (genetics)</term>
<term>Sequence Analysis, RNA (MeSH)</term>
<term>Soybean Proteins (genetics)</term>
<term>Soybean Proteins (metabolism)</term>
<term>Soybeans (genetics)</term>
<term>Soybeans (immunology)</term>
<term>Soybeans (parasitology)</term>
<term>Spliceosomes (genetics)</term>
<term>Spliceosomes (metabolism)</term>
<term>Virulence Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN des plantes (génétique)</term>
<term>Analyse de séquence d'ARN (MeSH)</term>
<term>Facteurs de virulence (métabolisme)</term>
<term>Immunité des plantes (génétique)</term>
<term>Interactions hôte-pathogène (génétique)</term>
<term>Interactions hôte-pathogène (immunologie)</term>
<term>Maladies des plantes (génétique)</term>
<term>Maladies des plantes (immunologie)</term>
<term>Phytophthora (pathogénicité)</term>
<term>Phytophthora (physiologie)</term>
<term>Protéines de soja (génétique)</term>
<term>Protéines de soja (métabolisme)</term>
<term>Précurseurs des ARN (génétique)</term>
<term>Régulation de l'expression des gènes végétaux (immunologie)</term>
<term>Soja (génétique)</term>
<term>Soja (immunologie)</term>
<term>Soja (parasitologie)</term>
<term>Splicéosomes (génétique)</term>
<term>Splicéosomes (métabolisme)</term>
<term>Épissage alternatif (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Precursors</term>
<term>RNA, Plant</term>
<term>Soybean Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Host-Pathogen Interactions</term>
<term>Plant Diseases</term>
<term>Plant Immunity</term>
<term>Soybeans</term>
<term>Spliceosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN des plantes</term>
<term>Immunité des plantes</term>
<term>Interactions hôte-pathogène</term>
<term>Maladies des plantes</term>
<term>Protéines de soja</term>
<term>Précurseurs des ARN</term>
<term>Soja</term>
<term>Splicéosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interactions hôte-pathogène</term>
<term>Maladies des plantes</term>
<term>Régulation de l'expression des gènes végétaux</term>
<term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Gene Expression Regulation, Plant</term>
<term>Host-Pathogen Interactions</term>
<term>Plant Diseases</term>
<term>Soybeans</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Soybean Proteins</term>
<term>Spliceosomes</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de virulence</term>
<term>Protéines de soja</term>
<term>Splicéosomes</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Soja</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Soybeans</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Phytophthora</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alternative Splicing</term>
<term>Sequence Analysis, RNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence d'ARN</term>
<term>Épissage alternatif</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The process of RNA splicing influences many physiological processes, including plant immunity. However, how plant parasites manipulate host RNA splicing process remains unknown. Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant pathogen Phytophthora sojae, physically binds to and stabilizes soybean serine/lysine/arginine-rich proteins GmSKRPs. The SKRPs are novel proteins that associate with a complex that contains plant spliceosome components, and are negative regulators of plant immunity. Analysis by RNA-seq data indicates that alternative splicing of pre-mRNAs from 401 soybean genes, including defense-related genes, is altered in GmSKRP1 and PsAvr3c overexpressing lines compared to control plants. Representative splicing events mediated by GmSKRP1 and PsAvr3c are tested by infection assays or by transient expression in soybean plants. Our results show that plant pathogen effectors can reprogram host pre-mRNA splicing to promote disease, and we propose that pathogens evolved such strategies to defeat host immune systems.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29233978</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>01</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>12</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>Nature communications</Title>
<ISOAbbreviation>Nat Commun</ISOAbbreviation>
</Journal>
<ArticleTitle>An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.</ArticleTitle>
<Pagination><MedlinePgn>2051</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41467-017-02233-5</ELocationID>
<Abstract><AbstractText>The process of RNA splicing influences many physiological processes, including plant immunity. However, how plant parasites manipulate host RNA splicing process remains unknown. Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant pathogen Phytophthora sojae, physically binds to and stabilizes soybean serine/lysine/arginine-rich proteins GmSKRPs. The SKRPs are novel proteins that associate with a complex that contains plant spliceosome components, and are negative regulators of plant immunity. Analysis by RNA-seq data indicates that alternative splicing of pre-mRNAs from 401 soybean genes, including defense-related genes, is altered in GmSKRP1 and PsAvr3c overexpressing lines compared to control plants. Representative splicing events mediated by GmSKRP1 and PsAvr3c are tested by infection assays or by transient expression in soybean plants. Our results show that plant pathogen effectors can reprogram host pre-mRNA splicing to promote disease, and we propose that pathogens evolved such strategies to defeat host immune systems.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Jie</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-6657-8740</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gu</LastName>
<ForeName>Lianfeng</ForeName>
<Initials>L</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-3810-2411</Identifier>
<AffiliationInfo><Affiliation>Basic Forestry and Proteomics Research Center, Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Tingxiu</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kong</LastName>
<ForeName>Guanghui</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kong</LastName>
<ForeName>Liang</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Baodian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Min</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jing</LastName>
<ForeName>Maofeng</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xing</LastName>
<ForeName>Weiman</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Wenwu</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-7347-8935</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Zhe</ForeName>
<Initials>Z</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-9436-3299</Identifier>
<AffiliationInfo><Affiliation>Department of Biology, South University of Science and Technology of China, Shenzhen, Guangdong, 518055, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Zhengguang</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Xiaobo</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gijzen</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-3715-6389</Identifier>
<AffiliationInfo><Affiliation>Agriculture and Agri-Food Canada, London, ON, N5V 4T3, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yuanchao</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-5803-5343</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Suomeng</ForeName>
<Initials>S</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-9623-6776</Identifier>
<AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China. smdong@njau.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China. smdong@njau.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>12</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nat Commun</MedlineTA>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
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<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
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</MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017381" MajorTopicYN="N">Spliceosomes</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
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<Month>10</Month>
<Day>27</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>11</Month>
<Day>14</Day>
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An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.

An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity.

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